Annable attended Valley Central High School and graduated in 1997.
He attended college at the State University of New York at Plattsburgh (SUNY Plattsburgh).
On April 5, 2016, it was announced that Annable joined the WWE Studio action film Temple alongside Wesley Snipes and Anne Heche.
Dave’s father is of German descent on one side, and of English, French, Irish, and German ancestry on the other side. Dave’s paternal grandfather was Herbert Rodman Annable (the son of Herbert Cecil Annable and Catherine S. Dave’s great-grandfather Herbert was born in Winchester, Dundas, Ontario, Canada, the son of Herbert Holmes Annable and Ethel Maud Durant.
Dave’s paternal grandmother was Ethel Martha Drutjons (the daughter of William Drutjons and Marie).
The WB reportedly showed interest in picking up the series on their network, but these plans never materialized.
In 2006, Annable was cast as Justin Walker on the ABC drama series Brothers & Sisters alongside Calista Flockhart, Rachel Griffiths, and Sally Field, which was picked up for a full season by the network.