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Newer findings reveal that psychoactive effects of classic psychedelics are mediated by the receptor heterodimer 5-HT agonists can be useful for the treatment of glaucoma.

This has led to the development of compounds such as AL-34662 that are hoped to reduce pressure inside the eyes but without crossing the blood–brain barrier and producing hallucinogenic side effects.

This inflexible pattern of emotional response often creates difficulty.

Some personality disorders are characterized by emotional sensitivity and a tendency to experience feelings with great intensity.

It is expressed near most of the serotoninergic terminal rich areas, including neocortex (mainly prefrontal, parietal, and somatosensory cortex) and the olfactory tubercle.

A very large family of derivatives from these three classes has been developed, and their structure-activity relationships have been extensively researched.

receptors located on the apical dendrites of pyramidal cells within regions of the prefrontal cortex are believed to mediate hallucinogenic activity.

Depending upon the type of personality disorder, affective (emotional) features can range from being very constricted, indifferent, cold, and experiencing little pleasure in life; to rapidly changing and wildly fluctuating emotions, often expressed with great intensity and dramatic flair.

In some personality disorders this lack of flexibility surrounding emotional expression leads to problems with chronic anger and irritability, problems with extreme anxiety, or a complete lack of empathy.

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