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Since this reaction does not require the participation of enzymes, the variables regulating it in vivo are the glucose and protein concentrations, the protein’s half-life and its reactivity in terms of free amino groups, and cell permeability to glucose.While the role of AGEs and their capacity to predict cardiovascular disease (CVD) in type 2 diabetic patients is now recognized, the published literature on other hypothetical markers, such as s RAGE and es RAGE, is sparse and conflicting.The reason why the picture is still not clear probably lies in the fact that soluble RAGE levels in humans depend on two mechanisms, that is, alternative splicing of the RAGE gene (es RAGE) and cleavage of the full-length protein (s RAGE).Click below to let us know you read this article, and wiki How will donate to World Possible on your behalf.Thanks for helping us achieve our mission of helping everyone learn how to do anything.

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